p53-Mediated Oxidative Stress Enhances Indirubin-3'-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression

• Main Authors: Matharage Gayani Dilshara (Author), Ilandarage Menu Neelaka Molagoda (Author), Rajapaksha Gedara Prasad Tharanga Jayasooriya (Author), Yung Hyun Choi (Author), Cheol Park (Author), Kyoung Tae Lee (Author), Seungheon Lee (Author), Gi-Young Kim (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Indirubin-3′-monoxime (I3M) exhibits anti-proliferative activity in various cancer cells; however, its anti-cancer mechanism remains incompletely elucidated. This study revealed that I3M promotes the expression of death receptor 5 (DR5) and tumor necrosis factor (TNF)-related apoptosis-ind...