Acetylcysteine modulates sphingolipid levels by inhibiting neutral sphingomyelinase during aging in rat tissues

• Main Authors: Loay Khaled Hassouneh (Author), Salameh Odatallah Aldajah (Author), Manal Mamdouh Najdawi (Author), Zead Helmi Abudayeh (Author), Qais Ibrahim Abualassal (Author), Amajad Naji aburmelah (Author), Alaa Yahya Sirhan (Author)
• Format: Book
• Published: Polskie Towarzystwo Farmaceutyczne, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Old-age-associated pathologies usually coincide with altered sphingolipid metabolism. Changes in the level of sphingomyelin (SM) and ceramide are largely determined by the activation of neutral sphingomyelinase (nSMase) during aging. nSMase is a key enzyme in sphingolipid turnover; it generates cera...