The potential role of adjunctive ascorbic acid in the prevention of colistin-induced nephrotoxicity in critically ill patients: A retrospective study

• Main Authors: Khalid Al Sulaiman (Author), Ohoud Aljuhani (Author), Abdullah M. Alhammad (Author), Kholoud Al Aamer (Author), Sara Alshehri (Author), Abdulmohsen Alhuwahmel (Author), Abdullah Kharbosh (Author), Areej Alshehri (Author), Hanan Alshareef (Author), Ibrahim Al Sulaihim (Author), Albandari Alghamdi (Author), Shmeylan Al Harbi (Author), Ramesh Vishwakarma (Author), Numan Alabdan (Author), Yousef Alrajhi (Author), Abdulmalik Al Katheri (Author), Abeer A. Alenazi (Author), Mai Alalawi (Author), Ghassan Al Ghamdi (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Colistin is considered a valuable and last-resort therapeutic option for MDR gram-negative bacteria. Nephrotoxicity is the most clinically pertinent adverse effect of colistin. Vivo studies suggest that administering oxidative stress-reducing agents, such as ascorbic acid, is a promising...