PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1ΔHBS in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling

• Main Authors: Dezhong Wang (Author), Tianyang Zhao (Author), Yushuo Zhao (Author), Yuan Yin (Author), Yuli Huang (Author), Zizhao Cheng (Author), Beibei Wang (Author), Sidan Liu (Author), Minling Pan (Author), Difei Sun (Author), Zengshou Wang (Author), Guanghui Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN). In the present study, we showed that treatment with an FGF...