PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1ΔHBS in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling

• প্রধান লেখক: Dezhong Wang (লেখক), Tianyang Zhao (লেখক), Yushuo Zhao (লেখক), Yuan Yin (লেখক), Yuli Huang (লেখক), Zizhao Cheng (লেখক), Beibei Wang (লেখক), Sidan Liu (লেখক), Minling Pan (লেখক), Difei Sun (লেখক), Zengshou Wang (লেখক), Guanghui Zhu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN). In the present study, we showed that treatment with an FGF...