First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications

• Main Authors: Markus W. Löffler (Author), Julia Steinhilber (Author), Franz J. Hilke (Author), Sebastian P. Haen (Author), Hans Bösmüller (Author), Ivonne-Aidee (Author), Irina Bonzheim (Author), Antje Stäbler (Author), Ulrike Faust (Author), Ute Grasshoff (Author), Ingmar Königsrainer (Author), Hans-Georg Rammensee (Author), Lothar Kanz (Author), Alfred Königsrainer (Author), Stefan Beckert (Author), Olaf Riess (Author), Christopher Schroeder (Author)
• Format: Book
• Published: BMC, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The PTEN-hamartoma-tumor-syndrome (PHTS) is caused by germline mutations in Phosphatase and Tensin homolog (PTEN) and predisposes to the development of several typical malignancies. Whereas PTEN mutations have been implicated in the occurrence of malignant mesotheliomas, the gene...