Antioxidant Polyphenols of <i>Antirhea borbonica</i> Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke

• Main Authors: Janice Taïlé (Author), Matthieu Bringart (Author), Cynthia Planesse (Author), Jessica Patché (Author), Philippe Rondeau (Author), Bryan Veeren (Author), Patricia Clerc (Author), Anne Gauvin-Bialecki (Author), Steeve Bourane (Author), Olivier Meilhac (Author), David Couret (Author), Marie-Paule Gonthier (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic disorders related to obesity and type 2 diabetes are associated with aggravated cerebrovascular damages during stroke. In particular, hyperglycemia alters redox and inflammatory status, leading to cerebral endothelial cell dysfunction, blood-brain barrier (BBB) disruption and brain homeost...