Impact of time to antibiotics on clinical outcome in paediatric febrile neutropenia: a target trial emulation of 1685 episodesResearch in context

• Main Authors: Gabrielle M. Haeusler (Author), S Ghazaleh Dashti (Author), Fiona James (Author), Franz E. Babl (Author), Meredith L. Borland (Author), Julia E. Clark (Author), Bhavna Padhye (Author), Heather Tapp (Author), Frank Alvaro (Author), Trisha Soosay Raj (Author), Thomas Walwyn (Author), David S. Ziegler (Author), Leanne Super (Author), Lisa Hall (Author), Daniel K. Yeoh (Author), Coen Butters (Author), Brendan McMullan (Author), Diane M.T. Hanna (Author), Richard De Abreu Lourenco (Author), Monica A. Slavin (Author), Bob Phillips (Author), Karin A. Thursky (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: Prompt antibiotic administration for febrile neutropenia (FN) is standard of care, and targets of time to antibiotics (TTA) <60 min are common. We sought to determine the effect of TTA ≥60 versus <60 min on adverse outcomes (intensive care unit (ICU) admission or death) in...