Multiple Origins of Mutations in the mdr1 Gene--A Putative Marker of Chloroquine Resistance in P. vivax.

• Main Authors: Mette L Schousboe (Author), Samir Ranjitkar (Author), Rupika S Rajakaruna (Author), Priyanie H Amerasinghe (Author), Francisco Morales (Author), Richard Pearce (Author), Rosalyn Ord (Author), Toby Leslie (Author), Mark Rowland (Author), Nahla B Gadalla (Author), Flemming Konradsen (Author), Ib C Bygbjerg (Author), Cally Roper (Author), Michael Alifrangis (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Chloroquine combined with primaquine has been the recommended antimalarial treatment of Plasmodium vivax malaria infections for six decades but the efficacy of this treatment regimen is threatened by chloroquine resistance (CQR). Single nucleotide polymorphisms (SNPs) in the multidrug res...