A Combined Computer-Aided Approach to Drive the Identification of Potential Epitopes in Protein Therapeutics

• Egile Nagusiak: Bárbara Athayde Vaz Galvão da Silva (Egilea), Ana Marisa Chudzinski-Tavassi (Egilea), Kerly Fernanda Mesquita Pasqualoto (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background: The identification of fragment sequences, or motifs, within a therapeutic protein that may elicit an immune response when processed by T-cells can be provided by computer-aided approaches. Immunogenicity is a significant problem associated with protein therapeutics and should be investig...