Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK

• Main Authors: Dexuan Zhuang (Author), Shuangshuang Wang (Author), Huiting Deng (Author), Yuxin Shi (Author), Chang Liu (Author), Xue Leng (Author), Qun Zhang (Author), Fuxiang Bai (Author), Bin Zheng (Author), Jing Guo (Author), Xunwei Wu (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge that demands the development of effective new drugs. Phenformin has been shown to produce more potent anti-tumor activities than metformin on different tumors, however, not much is known about the i...