Gallbladder wall abnormality in biliary atresia of mouse Sox17+/− neonates and human infants

• Main Authors: Mami Uemura (Author), Mayumi Higashi (Author), Montri Pattarapanawan (Author), Shohei Takami (Author), Naoki Ichikawa (Author), Hiroki Higashiyama (Author), Taizo Furukawa (Author), Jun Fujishiro (Author), Yuki Fukumura (Author), Takashi Yao (Author), Tatsuro Tajiri (Author), Masami Kanai-Azuma (Author), Yoshiakira Kanai (Author)
• Format: Book
• Published: The Company of Biologists, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biliary atresia (BA) is characterized by the inflammation and obstruction of the extrahepatic bile ducts (EHBDs) in newborn infants. SOX17 is a master regulator of fetal EHBD formation. In mouse Sox17+/− BA models, SOX17 reduction causes cell-autonomous epithelial shedding together with the ectopic...