Long-term muscle-specific overexpression of DOK7 in mice using AAV9-tMCK-DOK7

• Main Authors: Yu-Ting Huang (Author), Hannah R. Crick (Author), Helena Chaytow (Author), Dinja van der Hoorn (Author), Abrar Alhindi (Author), Ross A. Jones (Author), Ralph D. Hector (Author), Stuart R. Cobb (Author), Thomas H. Gillingwater (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuromuscular junction (NMJ) dysfunction underlies several diseases, including congenital myasthenic syndromes (CMSs) and motor neuron disease (MND). Molecular pathways governing NMJ stability are therefore of interest from both biological and therapeutic perspectives. Muscle-specific kinase (MuSK)...