Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced

• Main Authors: Peter Seiron (Author), Anna Wiberg (Author), Enida Kuric (Author), Lars Krogvold (Author), Frode L Jahnsen (Author), Knut Dahl‐Jørgensen (Author), Oskar Skog (Author), Olle Korsgren (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Insulin deficiency in type 1 diabetes (T1D) is generally considered a consequence of immune‐mediated specific beta‐cell loss. Since healthy pancreatic islets consist of ~65% beta cells, this would lead to reduced islet size, while the number of islets per pancreas volume (islet density) wou...