Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques.

• Main Authors: Chelsea M Crooks (Author), Andrea M Weiler (Author), Sierra L Rybarczyk (Author), Mason I Bliss (Author), Anna S Jaeger (Author), Megan E Murphy (Author), Heather A Simmons (Author), Andres Mejia (Author), Michael K Fritsch (Author), Jennifer M Hayes (Author), Jens C Eickhoff (Author), Ann M Mitzey (Author), Elaina Razo (Author), Katarina M Braun (Author), Elizabeth A Brown (Author), Keisuke Yamamoto (Author), Phoenix M Shepherd (Author), Amber Possell (Author), Kara Weaver (Author), Kathleen M Antony (Author), Terry K Morgan (Author), Christina M Newman (Author), Dawn M Dudley (Author), Nancy Schultz-Darken (Author), Eric Peterson (Author), Leah C Katzelnick (Author), Angel Balmaseda (Author), Eva Harris (Author), David H O'Connor (Author), Emma L Mohr (Author), Thaddeus G Golos (Author), Thomas C Friedrich (Author), Matthew T Aliota (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV i...