Phase I clinical trial of idiotypic DNA vaccine administered as a complex with polyethylenimine to patients with B-cell lymphoma

• Main Authors: A. N. Meleshko (Author), N. A. Petrovskaya (Author), N. Savelyeva (Author), K. P. Vashkevich (Author), S. N. Doronina (Author), N. V. Sachivko (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We report on the design of a phase I, non-randomized, open-label study of idiotypic DNA vaccination in patients with B-cell non-Hodgkin's lymphoma (ISRCTN31090206). The study uses DNA fusion gene vaccination encoding patient-specific single chain variable fragment, or idiotype, linked to an imm...