A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls

• Autores principales: Maurits F. J. M. Vissers (Autor), Matthew D. Troyer (Autor), Eva Thijssen (Autor), Diana R. Pereira (Autor), | Jules A. A. C. Heuberger (Autor), Geert Jan Groeneveld (Autor), Sarah Huntwork‐Rodriguez (Autor)
• Formato: Libro
• Publicado: Wiley, 2023-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Increased leucine‐rich repeat kinase 2 (LRRK2) kinase activity is an established risk factor for Parkinson's disease (PD), and several LRRK2 kinase inhibitors are in clinical development as potential novel disease‐modifying therapeutics. This biomarker characterization study explored w...