Cationic Channel TRPV2 Overexpression Promotes Resistance to Cisplatin-Induced Apoptosis in Gastric Cancer Cells

• Main Authors: Simona Laurino (Author), Pellegrino Mazzone (Author), Vitalba Ruggieri (Author), Pietro Zoppoli (Author), Giovanni Calice (Author), Antonella Lapenta (Author), Mario Ciuffi (Author), Orazio Ignomirelli (Author), Giulia Vita (Author), Alessandro Sgambato (Author), Sabino Russi (Author), Geppino Falco (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gastric cancer (GC) is characterized by poor efficacy and modest clinical impact of current therapies, in which apoptosis evasion is relevant. Intracellular calcium homeostasis dysregulation is associated with apoptosis escaping, and aberrant expression of calcium regulator genes could promote GC dr...