Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery

• Main Authors: Matteo Mori (Author), Stefania Villa (Author), Laurent R. Chiarelli (Author), Fiorella Meneghetti (Author), Marco Bellinzoni (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MbtI from <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) is a Mg²⁺-dependent salicylate synthase, belonging to the chorismate-utilizing enzyme (CUE) family. As a fundamental player in iron acquisition, MbtI promotes the survival and pathogenicity of <...