Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records

• Main Authors: Katherine S. Ruth (Author), Robin N. Beaumont (Author), Jonathan M. Locke (Author), Jessica Tyrrell (Author), Carolyn J. Crandall (Author), Gareth Hawkes (Author), Timothy M. Frayling (Author), Julia K. Prague (Author), Kashyap A. Patel (Author), Andrew R. Wood (Author), Michael N. Weedon (Author), Anna Murray (Author)
• Format: Book
• Published: BMC, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Vasomotor symptoms (VMS) can often significantly impact women's quality of life at menopause. In vivo studies have shown that increased neurokinin B (NKB) / neurokinin 3 receptor (NK3R) signalling contributes to VMS, with previous genetic studies implicating the TACR3 gene l...