Synthesis and Anti-Angiogenic Activity of Novel c(RGDyK) Peptide-Based JH-VII-139-1 Conjugates

• Hoofdauteurs: George Leonidis (Auteur), Anastasia Koukiali (Auteur), Ioanna Sigala (Auteur), Katerina Tsimaratou (Auteur), Dimitris Beis (Auteur), Thomas Giannakouros (Auteur), Eleni Nikolakaki (Auteur), Vasiliki Sarli (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Peptide-drug conjugates are delivery systems for selective delivery of cytotoxic agents to target cancer cells. In this work, the optimized synthesis of JH-VII-139-1 and its c(RGDyK) peptide conjugates is presented. The low nanomolar SRPK1 inhibitor, JH-VII-139-1, which is an analogue of Alectinib,...