Synthesis and Anti-Angiogenic Activity of Novel c(RGDyK) Peptide-Based JH-VII-139-1 Conjugates

• Main Authors: George Leonidis (Author), Anastasia Koukiali (Author), Ioanna Sigala (Author), Katerina Tsimaratou (Author), Dimitris Beis (Author), Thomas Giannakouros (Author), Eleni Nikolakaki (Author), Vasiliki Sarli (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peptide-drug conjugates are delivery systems for selective delivery of cytotoxic agents to target cancer cells. In this work, the optimized synthesis of JH-VII-139-1 and its c(RGDyK) peptide conjugates is presented. The low nanomolar SRPK1 inhibitor, JH-VII-139-1, which is an analogue of Alectinib,...