Synthesis and Anti-Angiogenic Activity of Novel c(RGDyK) Peptide-Based JH-VII-139-1 Conjugates

Peptide-drug conjugates are delivery systems for selective delivery of cytotoxic agents to target cancer cells. In this work, the optimized synthesis of JH-VII-139-1 and its c(RGDyK) peptide conjugates is presented. The low nanomolar SRPK1 inhibitor, JH-VII-139-1, which is an analogue of Alectinib,...

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Principais autores: George Leonidis (Autor), Anastasia Koukiali (Autor), Ioanna Sigala (Autor), Katerina Tsimaratou (Autor), Dimitris Beis (Autor), Thomas Giannakouros (Autor), Eleni Nikolakaki (Autor), Vasiliki Sarli (Autor)
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Publicado em: MDPI AG, 2023-01-01T00:00:00Z.
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