Midkine-Notch2 Pathway Mediates Excessive Proliferation of Airway Smooth Muscle Cells in Chronic Obstructive Lung Disease

• Main Authors: Tang Deng (Author), Qifeng Huang (Author), Kaiwen Lin (Author), Jin Qian (Author), Qi Li (Author), Lihua Li (Author), Shuangqin Xu (Author), Hongfang Yun (Author), Hangfei Wang (Author), Xinxin Wu (Author), Heng Liu (Author), Guiyun Jin (Author), Xiaoran Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation-induced proliferation of airway smooth muscle cells (ASMCs) and subsequent airway remodeling is a hallmark of chronic obstructive lung disease (COPD). The role of midkine (MK) in COPD is unclear. In this work, we explored the role of MK-Notch2 signaling in COPD by inhibiting the express...