Modeling CaMKII-mediated regulation of L-type Ca2+ channels and ryanodine receptors in the heart

• Hlavní autoři: Joseph L Greenstein (Autor), Panagiota T Foteinou (Autor), Yasmin L Hashambhoy-Ramsay (Autor), Raimond L Winslow (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Excitation-contraction coupling (ECC) in the cardiac myocyte is mediated by a number of highly integrated mechanisms of intracellular Ca2+ transport. Voltage- and Ca2+-dependent L-type Ca2+ channels (LCCs) allow for Ca2+ entry into the myocyte, which then binds to nearby ryanodine receptors (RyRs) a...