Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.

• Main Authors: Franklin R Toapanta (Author), Paula J Bernal (Author), Stephanie Fresnay (Author), Thomas C Darton (Author), Claire Jones (Author), Claire S Waddington (Author), Christoph J Blohmke (Author), Gordon Dougan (Author), Brian Angus (Author), Myron M Levine (Author), Andrew J Pollard (Author), Marcelo B Sztein (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new human oral challenge model with wild-type Salmonella Typhi (S. Typhi) was recently developed. In this model, ingestion of 104 CFU of Salmonella resulted in 65% of subjects developing typhoid fever (referred here as typhoid diagnosis -TD-) 5-10 days post-challenge. TD criteria included meeting...