DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease

• Main Authors: Kazuko Takahashi-Niki (Author), Ayako Inafune (Author), Naruyuki Michitani (Author), Yoshitaka Hatakeyama (Author), Kotaro Suzuki (Author), Mai Sasaki (Author), Yoshihisa Kitamura (Author), Takeshi Niki (Author), Sanae M.M. Iguchi-Ariga (Author), Hiroyoshi Ariga (Author)
• Format: Book
• Published: Elsevier, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. Oxidative stress is one of the causes of PD. Since symptomatic PD therapies are used, identification of compounds or proteins that inhibit oxidative str...