DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease

• Hauptverfasser: Kazuko Takahashi-Niki (Verfasst von), Ayako Inafune (Verfasst von), Naruyuki Michitani (Verfasst von), Yoshitaka Hatakeyama (Verfasst von), Kotaro Suzuki (Verfasst von), Mai Sasaki (Verfasst von), Yoshihisa Kitamura (Verfasst von), Takeshi Niki (Verfasst von), Sanae M.M. Iguchi-Ariga (Verfasst von), Hiroyoshi Ariga (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2015-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Parkinson's disease (PD) is caused by dopaminergic cell death in the substantia nigra, leading to a reduced level of dopamine in the striatum. Oxidative stress is one of the causes of PD. Since symptomatic PD therapies are used, identification of compounds or proteins that inhibit oxidative str...