Spray-dried cyclophosphamide-loaded polyhydroxyalkanoate microparticles: design and characterization

• Main Authors: Sergei Lipaikin (Author), Aleksei Dorokhin (Author), Galina Ryltseva (Author), Andrey Oberenko (Author), Evgeniy Kiselev (Author), Alexander Shabanov (Author), Tatiana Volova (Author), Ekaterina Shishatskaya (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: Cyclophosphamide (CP) is a widely used antitumor and immunosuppressive drug, but it is highly cytotoxic and has carcinogenic and teratogenic potential. To reduce adverse effects of CP therapy and the frequency of its administration, the microencapsulation of CP into biodegrad...