A Comprehensive Physiologically Based Pharmacokinetic Model for Predicting Vildagliptin Pharmacokinetics: Insights into Dosing in Renal Impairment

• Main Authors: Mahnoor Pasha (Author), Ammara Zamir (Author), Muhammad Fawad Rasool (Author), Hamid Saeed (Author), Tanveer Ahmad (Author), Nawaf Shalih Alqahtani (Author), Lamya Saif Alqahtani (Author), Faleh Alqahtani (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Physiologically based pharmacokinetic (PBPK) modeling is of great importance in the field of medicine. This study aims to construct a PBPK model, which can provide reliable drug pharmacokinetic (PK) predictions in both healthy and chronic kidney disease (CKD) subjects. To do so, firstly a review of...