A Novel Imidazo[1,5-b]isoquinolinone Derivative, U63A05, Inhibits Syk Activation in Mast Cells to Suppress IgE-Mediated Anaphylaxis in Mice

• Main Authors: Do Kyun Kim (Author), Jun Ho Lee (Author), Jie Wan Kim (Author), Hyuk Soon Kim (Author), A-Ram Kim (Author), Bo Kyung Kim (Author), Kyu Yang Yi (Author), Hye-Jin Park (Author), Dong Ki Park (Author), Wahn Soo Choi (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mast cells play a pivotal role in IgE-mediated allergic responses. Development of specific inhibitors against FcεRI-associated proximal signaling molecules in mast cells may represent a promising therapeutic strategy for allergic diseases. We examined whether a novel synthetic compound, 3-butyl-1-ch...