A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice.

• Main Authors: Viswanathan Ramasamy (Author), Upasana Arora (Author), Rahul Shukla (Author), Ankur Poddar (Author), Rajgokul K Shanmugam (Author), Laura J White (Author), Melissa M Mattocks (Author), Rajendra Raut (Author), Ashiya Perween (Author), Poornima Tyagi (Author), Aravinda M de Silva (Author), Siddhartha K Bhaumik (Author), Murali Krishna Kaja (Author), François Villinger (Author), Rafi Ahmed (Author), Robert E Johnston (Author), Sathyamangalam Swaminathan (Author), Navin Khanna (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue is one of the fastest spreading vector-borne diseases, caused by four antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible for both protection as well as pathogenesis. A vaccine that is safe for and efficacious in all people irrespective of their age and dom...