Enrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARS-COV-2

• Main Authors: Sophia Liu (Author), Yuetian Yan (Author), Cody M. Secor (Author), Zachary R. Oberholtzer (Author), Donna J. Skow (Author), Mushhood Sheikh (Author), Youmi Moon (Author), Yue Fu (Author), Cristinel Sandu (Author), Shunhai Wang (Author), Ning Li (Author), Jennifer B. Nguyen (Author), Michael P. Rosconi (Author), Erica A. Pyles (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTCo-formulation of multiple drug products is an efficient and convenient approach to simultaneously deliver multiple biotherapeutics with the potentially added benefit of a synergistic therapeutic effect. However, co-formulation also increases the risk of heteromeric interactions, giving rise...