Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma

• Main Authors: Jing Lin (Author), Jia Hui Jane Lee (Author), Kathirvel Paramasivam (Author), Elina Pathak (Author), Zhenxun Wang (Author), Zacharias Aloysius Dwi Pramono (Author), Bing Lim (Author), Keng Boon Wee (Author), Uttam Surana (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Self-renewing tumor-initiating cells (TICs) are thought to be responsible for tumor recurrence and chemo-resistance. Glycine decarboxylase, encoded by the GLDC gene, is reported to be overexpressed in TIC-enriched primary non-small-cell lung carcinoma (NSCLC). GLDC is a component of the mitochondria...