Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect in vivo and drug-like properties

In order to obtain topical and non-irritating anti-glaucoma drugs, novel semicarbazide-containing sulfonamide derivatives were designed and synthetized by sugar tail method in this study. The hydrophilic monosaccharides were expected to form interaction with the hydrophilic site of hCA II meanwhile...

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Main Authors: Yingxia Xie (Author), Xiaoyi Wang (Author), Hao Jia (Author), Naying Chu (Author)
Format: Book
Published: Elsevier, 2024-03-01T00:00:00Z.
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3rd Floor Main Library

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