Synthesis, molecular modelling and QSAR study of new N-phenylacetamide-2-oxoindole benzensulfonamide conjugates as carbonic anhydrase inhibitors with antiproliferative activity

In continuation of our previous studies to optimise potent carbonic anhydrase inhibitors, two new series of isatin N-phenylacetamide based sulphonamides were synthesised and screened for their human (h) carbonic anhydrase (EC 4.2.1.1) inhibitory activities against four isoforms hCA I, hCA II, hCA IX...

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Auteurs principaux: Mona F. Said (Auteur), Riham F. George (Auteur), Andrea Petreni (Auteur), Claudiu T. Supuran (Auteur), Nada M. Mohamed (Auteur)
Format: Livre
Publié: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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