Proteomic profiling of the brain from the <i>wobbler</i> mouse model of amyotrophic lateral sclerosis reveals elevated levels of the astrogliosis marker glial fibrillary acidic protein

• Main Authors: Sandra Murphy (Author), Thomas Schmitt-John (Author), Paul Dowling (Author), Michael Henry (Author), Paula Meleady (Author), Dieter Swandulla (Author), Kay Ohlendieck (Author)
• Format: Book
• Published: PAGEPress Publications, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The wobbler mouse is a widely used model system of amyotrophic lateral sclerosis and exhibits progressive neurodegeneration and neuroinflammation in association with skeletal muscle wasting. This study has used wobbler brain preparations for the systematic and mass spectrometric determination of pro...