A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection

• Main Authors: Hui Jiang (Author), Yaping Zhao (Author), Meiming Su (Author), Lu Sun (Author), Meijie Chen (Author), Zhidan Zhang (Author), Iqra Ilyas (Author), Zhihua Wang (Author), Peter J. Little (Author), Li Wang (Author), Jianping Weng (Author), Jianjun Ge (Author), Suowen Xu (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aortic dissection (AD) is a fatal cardiovascular disease with limited pharmacotherapies. To discover novel therapeutic targets for AD, the present study was conducted on ascending aorta samples from AD patients versus those from control subjects using proteomic analysis. Integrated proteomic data an...