Comparison of LC-MS/MS and EMIT methods for the precise determination of blood sirolimus in children with vascular anomalies

• Main Authors: Yue-Tao Zhao (Author), Hao-Ran Dai (Author), Yue Li (Author), Yuan-Yuan Zhang (Author), Hong-Li Guo (Author), Xuan-Sheng Ding (Author), Ya-Hui Hu (Author), Feng Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirolimus (SRL) is a mammalian target of rapamycin (mTOR) inhibitor. The whole blood concentration of SRL is routinely monitored to tailor dosage and prevent toxicity. Currently, the enzyme multiplied immunoassay technique (EMIT) is often applied to perform therapeutic drug monitoring (TDM) of SRL,...