ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1α/PPARα pathway: integration of WGCNA, machine learning and experimental validation

• Main Authors: Li Song (Author), Shuo Huang (Author), Honghao Yan (Author), Qing Ma (Author), Qihan Luo (Author), Jiang Qiu (Author), Minxia Chen (Author), Zongyuan Li (Author), He Jiang (Author), Yufan Chen (Author), Fangming Chen (Author), Yu Du (Author), Haozhe Fu (Author), Lisha Zhao (Author), Kanglu Zhao (Author), Ping Qiu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundAlcoholic hepatitis is a severe inflammatory liver disease. In recent years, the incidence of AH has been on the rise, leading to an increasingly severe disease burden. Currently, there is a lack of specific biomarkers for the diagnosis and prognosis of AH in clinical practice. Therefore,...