Right Dose, Right Now: Development of AutoKinetics for Real Time Model Informed Precision Antibiotic Dosing Decision Support at the Bedside of Critically Ill Patients

• Main Authors: Luca F. Roggeveen (Author), Tingjie Guo (Author), Ronald H. Driessen (Author), Lucas M. Fleuren (Author), Patrick Thoral (Author), Peter H. J. van der Voort (Author), Armand R. J. Girbes (Author), Rob J. Bosman (Author), Paul Elbers (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionAntibiotic dosing in critically ill patients is challenging because their pharmacokinetics (PK) are altered and may change rapidly with disease progression. Standard dosing frequently leads to inadequate PK exposure. Therapeutic drug monitoring (TDM) offers a potential solution but requi...