Long-Term Angiotensin II Blockade May Improve Not Only Hyperglycemia but Also Age-Associated Cardiac Fibrosis

• Main Authors: Denan Jin (Author), Shinji Takai (Author), Tetsuya Sugiyama (Author), Tetsuya Hayashi (Author), Masanori Fukumoto (Author), Hidehiro Oku (Author), Yasushi Kitaura (Author), Tsunehiko Ikeda (Author), Mizuo Miyazaki (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, the effects of long-term angiotensin (Ang) II antagonism on the development of cardiac and endothelial disorders were examined in Spontaneously Diabetic Torii (SDT) rats. Blood glucose concentration started to increase markedly in the untreated SDT rats from 20 weeks of age, wh...