Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia

• Main Authors: Mark W. Cunningham (Author), Aswathi Jayaram (Author), Evangeline Deer (Author), Lorena M. Amaral (Author), Venkata Ramana Vaka (Author), Tarek Ibrahim (Author), Denise C. Cornelius (Author), Babbette LaMarca (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS).  Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats. Methods: On...