Human tissue models in cancer research: looking beyond the mouse

• मुख्य लेखकों: Samuel J. Jackson (लेखक), Gareth J. Thomas (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2017-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Mouse models, including patient-derived xenograft mice, are widely used to address questions in cancer research. However, there are documented flaws in these models that can result in the misrepresentation of human tumour biology and limit the suitability of the model for translational research. A c...