Simultaneous Quantitation of a Novel α1/β1-Blocker TJ0711 and Its Two Metabolites in Dog Plasma Using LC-MS/MS and Its Application to a Pharmacokinetic Study after Intravenous Infusion

• Hoofdauteurs: Wenwen Zhu (Auteur), Wanyu Liu (Auteur), Haojv Li (Auteur), Guojia Xu (Auteur), Qian Li (Auteur), Jiangeng Huang (Auteur), Gao Li (Auteur), Luqin Si (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2019-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

TJ0711∙HCl, which is a novel α1/β1 adrenoceptor blocking agent with a ratio of 1:1 for α1/β1, is designed to treat and prevent perioperative hypertension. M1 and M3 were identified as important metabolites in vitro for either antihypertension activity or the maj...