Phosphatidylinositol-3 kinase-Akt-mammalian target of rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising new target for the treatment of endometriosis-associated fibrosis

• Main Authors: Wakana Abe (Author), Kaei Nasu (Author), Akitoshi Tsuno (Author), Yukie Kawano (Author), Hisashi Narahara (Author)
• Formato: Livro
• Publicado em: Wolters Kluwer Medknow Publications, 2014-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Objective: To assess the involvement of phosphatidylinositol-3 kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) on the extracellular matrix contractility of endometriotic cells. Materials and methods: The effects of wortmannin, LY294002, Akt inhibitor IV, and Ku-0063794 on the contractility of...