Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

• Main Authors: SiChan Li (Author), SanLan Wu (Author), WeiJing Gong (Author), Peng Cao (Author), Xin Chen (Author), Wanyu Liu (Author), Liping Xiang (Author), Yang Wang (Author), JianGeng Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The aims of this study were to establish a joint population pharmacokinetic model for voriconazole and its N-oxide metabolite in immunocompromised patients, to determine the extent to which the CYP2C19 genetic polymorphisms influenced the pharmacokinetic parameters, and to evaluate and opti...