Population Pharmacokinetics of Levetiracetam and Dosing Evaluation in Critically Ill Patients with Normal or Augmented Renal Function

• Main Authors: Idoia Bilbao-Meseguer (Author), Helena Barrasa (Author), Eduardo Asín-Prieto (Author), Ana Alarcia-Lacalle (Author), Alicia Rodríguez-Gascón (Author), Javier Maynar (Author), José Ángel Sánchez-Izquierdo (Author), Goiatz Balziskueta (Author), María Sánchez-Bayton Griffith (Author), Nerea Quilez Trasobares (Author), María Ángeles Solinís (Author), Arantxa Isla (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Levetiracetam is a broad-spectrum antiepileptic drug commonly used in intensive care units (ICUs). The objective of this study is to evaluate the adequacy of levetiracetam dosing in patients with normal or augmented renal clearance (ARC) admitted to the ICU by population modelling and simulation. A...