Sphingosine kinase 1 promotes growth of glioblastoma by increasing inflammation mediated by the NF-κB /IL-6/STAT3 and JNK/PTX3 pathways

• Main Authors: Wan Li (Author), Hongqing Cai (Author), Liwen Ren (Author), Yihui Yang (Author), Hong Yang (Author), Jinyi Liu (Author), Sha Li (Author), Yizhi Zhang (Author), Xiangjin Zheng (Author), Wei Tan (Author), Guanhua Du (Author), Jinhua Wang (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma (GBM) is the most challenging malignant tumor of the central nervous system because of its high morbidity, mortality, and recurrence rate. Currently, mechanisms of GBM are still unclear and there is no effective drug for GBM in the clinic. Therefore, it is urgent to identify new drug ta...