Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

• Main Authors: Wenkang Fu (Author), Yanyan Lin (Author), Mingzhen Bai (Author), Jia Yao (Author), Chongfei Huang (Author), Long Gao (Author), Ningning Mi (Author), Haidong Ma (Author), Liang Tian (Author), Ping Yue (Author), Yong Zhang (Author), Jinduo zhang (Author), Yanxian Ren (Author), Liyun Ding (Author), Lunzhi Dai (Author), Joseph W. Leung (Author), Jinqiu Yuan (Author), Wenhua Zhang (Author), Wenbo Meng (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cholangiocarcinoma (CCA) is a bile duct malignancy with a dismal prognosis. This study systematically investigated the role of the ribosomal protein S6 (RPS6) gene, which is dependent in CCA. We found that RPS6 upregulation in CCA tissues was correlated with a poor prognosis. Functional investigatio...