Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis

• 主要な著者: Nazi Song (著者), Hongjiao Xu (著者), Jiahua Liu (著者), Qian Zhao (著者), Hui Chen (著者), Zhibin Yan (著者), Runling Yang (著者), Zhiteng Luo (著者), Qi Liu (著者), Jianmei Ouyang (著者), Shuohan Wu (著者), Suijia Luo (著者), Shuyin Ye (著者), Runfeng Lin (著者), Xi Sun (著者), Junqiu Xie (著者), Tian Lan (著者), Zhongdao Wu (著者), Rui Wang (著者), Xianxing Jiang (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2022-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor (GLP-1R/GCGR) agonist with higher affinity towards GCGR, could retard the progression of liver f...