P-glycoprotein polymorphism and levothyroxine bioavailability in hypothyroid patients

• Main Authors: Ezgi Öztaş (Author), Alejandro Parejo Garcia-Saavedra (Author), Fatih Yanar (Author), Beyza Özçinar (Author), Nihat Aksakal (Author), Sevim Purisa (Author), Gül Özhan (Author)
• Format: Book
• Published: Elsevier, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: P-glycoprotein (P-gp) contributes to the disposition of a wide variety of drugs; therefore, single nucleotide polymorphisms (SNPs) in the P-gp coding gene might affect its activity. It is well known that personalized medicine, instead of empirical treatment, is a clinically important app...