MBD2 Mediates Septic AKI through Activation of PKCη/p38MAPK and the ERK1/2 Axis

• Main Authors: Yuxin Xie (Author), Bohao Liu (Author), Jian Pan (Author), Jiamiao Liu (Author), Xiaozhou Li (Author), Huiling Li (Author), Shuangfa Qiu (Author), Xudong Xiang (Author), Peiling Zheng (Author), Junxiang Chen (Author), Yunchang Yuan (Author), Zheng Dong (Author), Dongshan Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our previous study demonstrated that the methyl-CpG-binding domain protein 2 (MBD2) mediates vancomycin (VAN)-induced acute kidney injury (AKI). However, the role and regulation of MBD2 in septic AKI are unknown. Herein, MBD2 was induced by lipopolysaccharide (LPS) in Boston University mouse proxima...