Polymorphisms in Glyoxalase I Gene Are Not Associated with Glyoxalase I Expression in Whole Blood or Markers of Methylglyoxal Stress: The CODAM Study

• Hauptverfasser: Kim Maasen (Verfasst von), Nordin M. J. Hanssen (Verfasst von), Carla J. H. van der Kallen (Verfasst von), Coen D. A. Stehouwer (Verfasst von), Marleen M. J. van Greevenbroek (Verfasst von), Casper G. Schalkwijk (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2021-02-01T00:00:00Z.
• Schlagworte: article
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Glyoxalase 1 (Glo1) is the rate-limiting enzyme in the detoxification of methylglyoxal (MGO) into D-lactate. MGO is a major precursor of advanced glycation endproducts (AGEs), and both are associated with development of age-related diseases. Since genetic variation in <i>GLO1</i> may alt...